Coordination of glutaminolysis and glycolysis in cancer cells (ESR 3)
Project Description
1) Job Summary: ESR (Early Stage Researcher) position for 36 month at the Institute of Veterinary Physiology and Biochemistry, Justus-Liebig-University of Giessen, Germany.
2) Job description: Application refers to an Early Stage Researcher (ESR) position to be trained at the Department of Veterinary Physiology and Biochemistry , University of Giessen, in the framework of the TRANSMIT project.
Cancer cell proliferation strongly depends on the availability of energy and metabolic precursors for the synthesis of cell building blocks which implies a close coordination between the associated key pathways glycolysis and glutaminolysis. The ESR will investigate the effect of different nutrient deficiency protocols as well as inhibitors of selected cytosolic and mitochondrial enzymes on the composition of the glycolytic enzyme complex as well as the coordination of the glycolytic and glutaminolytic conversion rates in tumor cell lines with different metabolic characteristics. In selected cell models with most effective treatment protocols the metabolic fate of glucose and glutamine will be determined using mass spectrometry.
Principal Investigator: Prof. Sybille Mazurek
ESR 3: Floriana Jessica Di Paola
Key personnel:
Dr. Carmen Rauschenbach, Post-Doc fellow
